Study Suggests Breakthrough in Organ Transplants


March 8, 2012

Los Angeles Times

Abraham Shaked, MD, PhD, director of the Penn Transplant Center and chief of the division of Transplantation Surgery, is quoted in a Los Angeles Times article about a new study published this week suggesting that patients receiving an organ that's less than a perfect match can be protected against rejection by a second transplant — this time of the organ donor's imperfectly matched stem cells. Shaked said despite the success detailed in the paper, uncertainties persist: It's not clear, for one thing, whether patients who are enabled to tolerate a mismatched kidney also have weakened "early warning" responses to infections and cancers. Still, he called the results "absolutely remarkable" and "beyond any expectations." Read More