T-Cell Immunotherapy for Leukemia

Penn researchers recently presented findings from the CAR T Cell clinical trial at the American Society of Hematology (ASH) annual meeting.

Penn's cancer research team is currently enrolling new adult patients with chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL) to participate in these clinical trials.


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How T-Cell Immunotherapy for Leukemia Works

  • A patient's own immune cells (T cells) are removed from the blood and genetically modified or reprogrammed in the laboratory.
  • This modification or reprogramming allows them to potentially target and kill their own malignant cells. The modified cells (CTL019 cells) are then grown in the laboratory and re-infused into the patient.
  • When the patient's own T-cells recognize and bind to the malignant cell, they have the ability to become activated and kill it.

Cancer Treatment at Penn

If you are interested in chronic lymphocytic leukemia or acute lymphoblastic leukemia treatment at Penn, or to schedule an appointment with a cancer physician specializing in immunotherapy call 800-789-PENN (7366) or request an appointment online.



Genetically Modified T Cells Obliterate Chronic Lymphocytic Leukemia Tumors

Researchers at Penn's Abramson Cancer Center have molecularly engineered T-cells from patients with chronic lymphocytic leukemia and re-introduced them with remarkable success.


Penn Medicine's Carl June, MD, Wins Philadelphia Award

Carl June, MDCarl June, MD, the Richard W. Vague Professor in Immunotherapy in the department of Pathology and Laboratory Medicine and director of Translational Research in Penn's Abramson Cancer Center, was named the winner of the 92nd annual Philadelphia Award. Read more...