Program Leader(s): Robert Vonderheide, MD, DPhil
The goal of the Immunobiology Program is to understand more fully the basic mechanisms of immune cell function, to gain insight into the pathogenesis of malignancies within this organ system and to provide a rational basis for immunological therapies of neoplasia. To this end, researchers participating in our Program study diverse features of immunology, from the most basic molecular mechanisms of lymphocyte activation, to translational projects designed to optimize therapies for patients. Model systems and approaches employed span in vitro molecular studies to investigations in cell lines, generation and analysis of novel genetically altered mice, and finally development of new clinical protocols to treat patients with various malignancies. Investigators in the Program are addressing fundamental questions relevant to both the innate and adaptive immune response.