What is the purpose of Project HOPE?

Project HOPE is a randomized controlled exercise and nutrition intervention trial for breast cancer survivors who have tested positive for the BRCA1 or BRCA2 mutation, have undergone surgical removal of their ovaries by age 45, have not taken HRT for two years, and who are, as a result, at increased risk for negative long term cardiovascular, metabolic and bone health outcomes. The intervention is a commercially available web-based weight loss program which has been pilot tested by our study team among young breast cancer survivors. Six months into the pilot, young breast cancer survivors (mean age 43) lost an average of 5.3% of their body weight, which is comparable to other web-based interventions conducted in healthy populations.

Project HOPE is innovating the use of a web-based behavioral intervention for the primary prevention of cardiovascular and metabolic outcomes in an understudied, high risk group of cancer survivors. The intervention has advantages in terms of cost-effectiveness and accessibility to the larger survivor community compared to standard programs. If this study provides preliminary evidence of efficacy and safety, a larger trial would be proposed in partnership with the advocacy group 'FORCE'. Our team has a strong collaborative connection with FORCE through the recently completed WISER Sister trial.

Project HOPE is an outgrowth of 2 prior studies: the ICAN study and WISER Sister.