Autophagy Inhibition May Help Overcome BRAF Inhibitor Resistance in Melanoma


March 27, 2014

Blocking autophagy with the antimalarial drug hydroxycholoroquine (HCQ) may help melanoma patients overcome resistance to BRAF inhibitors, according to a new Penn Medicine study, reports HemOnc Today . Researchers, including lead author Ravi K. Amaravadi, MD , assistant professor of medicine in the division of Hematology/Oncology, found the root of the resistance may lie in a never-before-seen autophagy mechanism induced by BRAF inhibitors. Block this pathway with the HCQ, and the inhibitors will be able to do their job better. “This study opens the door for combination therapy with BRAF inhibitors and autophagy inhibitors which haven’t been explored deeply as a therapeutic option for patients whose tumors are resistant,” he said.

HemOnc Today article