The Editor's Choice column of Science magazine highlights a recent Cell Reports paper from the lab of Ken Zaret, PhD, professor of Cell and Developmental Biology, and the Institute for Regenerative Medicine: "Kim et al. have now generated an iPSC line from a late-stage human pancreatic cancer. The cells resemble the human cancer cells in morphology and histology, and when these cells were injected into immunode?cient mice, pancreatic intraepithelial neoplasia lesions progressed to invasive PDAC. An analysis of these cells identi?ed proteins that are secreted or released, as well as networks, such as TGFß1 and integrin signaling. In particular, the HNF4A pathway is speci?c for early to intermediate stages of progression."
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