Penn Study Finds More Effective Approach Against "Achilles Heel" of Ovarian Cancer

August 10, 2011

Penn Medicine News Release

In a recent issue of Cancer Research, Daniel J. Powell, Jr., PhD, research assistant professor of Pathology and Laboratory Medicine and Obstetrics and Gynecology, showed for the first time that engineered human T cells can eradicate deadly human ovarian cancer in immune-deficient mice. Ovarian cancer is the most lethal reproductive cancer for women, with one-fifth of women diagnosed with advanced disease surviving five years. Nearly all ovarian cancers (90%) are characterized by their expression of a distinct cell-surface protein called alpha-folate receptor, which can be a target for engineered T cells... Read More