Penn Medicine News Release
ORLANDO -- Researchers at the University of Pennsylvania School of Medicine
may have found a way to turn an adaptive cellular response into a
liability for cancer cells. When normal cells are starved for food, they
chew up existing proteins and membranes to stay alive. Cancer cells
have corrupted that process, called autophagy, using it to survive when
they run out of nutrients and to evade death after damage from
chemotherapy and other sources. When the Penn investigators treated a
group of patients with several different types of advanced cancers with
temsirolimus, a molecularly targeted cancer drug that blocks nutrient
uptake, plus hydroxychloroquine, an anti-malarial drug that inhibits
autophagy, they saw that tumors stopped growing in two-thirds of the
patients... Read More
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