Penn Scientists Identify New Role for Protein Molecule That Inhibits Response of Immune-System Cells


November 8, 2010

Penn News

PHILADELPHIA -– Researchers at the University of Pennsylvania have identified a new role for a protein molecule that inhibits the response of immune-system cells to inflammatory signals associated with many human diseases.           

An international group of scientists, with lead researchers in Penn’s School of Veterinary Medicine and School of Medicine, has shown the unique ability of a protein subunit called IL-27p28 to bind with a key cell receptor (gp130), effectively preventing it from transmitting signals necessary for triggering an immune response.  Regulating the production of the molecule could lead to new, targeted interventions for cancer, asthma, lupus, multiple sclerosis, arthritis and other diseases... READ MORE