Penn Medicine News Brief
Women who have inherited mutations in the BRCA1 or BRCA2 (BRCA1/2)
genes have substantially elevated risks of developing breast and
ovarian cancer. A study that will appear in the September 1 issue of The Journal of the American Medical Association
(JAMA) reports that women with these inherited mutations who have had a
prophylactic mastectomy or salpingo-oophorectomy (removal of the
fallopian tubes and ovaries) had an associated decreased risk of breast
cancer and ovarian cancer.
Corresponding author Timothy R. Rebbeck, PhD, Leader, Cancer for Center Genetics, Epidemiology and Risk Reduction Program at the University of Pennsylvania and Susan Domchek, MD, associate professor of Medicine at the University of Pennsylvania Abramson Cancer Center,
and their colleagues conducted a study that looked at a large group of
BRCA1/2 mutation carriers to determine reduction estimates following
risk-reducing surgeries... Read More
View JAMA Video News Release
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