Preventive Surgeries Linked to Lower Risk of Cancer for Women with BRCA1/2 Gene Mutations


August 31, 2010

Penn Medicine News Brief
Women who have inherited mutations in the BRCA1 or BRCA2 (BRCA1/2) genes have substantially elevated risks of developing breast and ovarian cancer.  A study that will appear in the September 1 issue of The Journal of the American Medical Association (JAMA) reports that women with these inherited mutations who have had a prophylactic mastectomy or salpingo-oophorectomy (removal of the fallopian tubes and ovaries) had an associated decreased risk of breast cancer and ovarian cancer.

Corresponding author Timothy R. Rebbeck, PhD, Leader, Cancer for Center Genetics, Epidemiology and Risk Reduction Program at the University of Pennsylvania and Susan Domchek, MD, associate professor of Medicine at the University of Pennsylvania Abramson Cancer Center, and their colleagues conducted a study that looked at a large group of BRCA1/2 mutation carriers to determine reduction estimates following risk-reducing surgeries... Read More

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