Chemical & Engineering News
In the 1920s, German biochemist Otto Heinrich Warburg noticed a metabolic quirk in cancer cellsthey break down glucose via an oxygen-free metabolic pathway, regardless of whether oxygen is available.
Today, a reinvigoration of Warburg's ideas is
afoot, and it is a harbinger of a larger effort to determine the
relationships between metabolism and cancer. Indeed, that multifaceted
relationship will be the topic of an upcoming Keystone symposium in March. And just last week, pharmaceutical giant AstraZeneca announced a partnership with Cancer Research Technology, the commercial arm of the U.K.'s largest independent cancer research funder, to develop cancer metabolism drugs (see Business Concentrates, page 28). Growing interest in this area of research is also evident in recently published studies... read more