Penn Medicine News Release
PHILADELPHIA – Scientists at the University of Pennsylvania School of Medicine
have developed a new model of skin cancer based on the knowledge that a
common cancer-related molecule called Src kinase is activated in human
skin-cancer samples.
“Our previous work demonstrated that Src kinases are activated in human
squamous cell carcinomas of the skin. We modeled these observations by
increasing the expression of the gene Fyn, a member of Src family of proteins, in mouse skin,” explains senior author John T. Seykora MD, PhD, assistant professor of Dermatology.
In addition, prior work by the Seykora lab on a related protein called
Srcasm, discovered by him in 2002, suggested that Srcasm may function
as an anti-oncogene, a molecule that keeps others in check in order to
control cell growth... Read More
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