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Anil K. Rustgi, MD

Abramson Cancer Center

Degree and Institution

MD, Duke University

Faculty Title

T. Grier Miller Professor of Medicine & Genetics

Administrative Title

Chief, Gastroenterology Division; Director, Digestive & Liver Center

Abramson Cancer Center Title

Co-Program Leader, Tumor Biology Program


Clinical Expertise

GI cancers, familial GI cancers, Barrett's esophagus, colonic polyps

Research Expertise

Our laboratory has had long-standing thematic interests in the cell-type and tissue-type specific actions of certain oncogenes (cyclin D1, Ki-Ras, EGFR) and tumor suppressor genes (p53, p16INK4a) in modulating the initiation, progression and invasion of gastrointestinal cancers, especially upper GI, pancreatic and colon. To that end, we employ novel three-dimensional cell culture systems (mouse and human origins) and geneticaly-engineered mouse models to investigate molecular mechanisms. These projects are translated into the objectives of improving molecular diagnostics and experimental therapeutics in patients. Our research is funded through an NCI program project entitled Mechanisms of Esophageal Carcinogenesis, NIH R01 grant on pancreatic cancer, and NIH R01 grant on colon cancer. Students and postdoctoral fellows are supported in didactic venues and conferences, present at national meeting, and have obtained national grant fellowships when applicable.

Cancer Programs
Gastrointestinal Cancer Program
» Gastrointestinal Medicine

Gastrointestinal Cancer Evaluation Center (GICEC)
» GI Cancer Evaluation Center

Gastrointestinal (GI) Cancer Risk Evaluation Program
» GI Cancer Risk Evaluation Program

Beth Israel Hospital, Harvard Medical School

Massachusetts General Hospital, Harvard Medical School

Board Certifications
Internal Medicine; Gastroenterology

Honors and Award

Department Honors in Molecular Biophysics and Biochemistry, Yale University


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Contact Information

Anil Rustgi

Gastroenterology Division
University of Pennsylvania School of Medicine
600 Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104

Office Phone: (215) 898-0154
Fax: (215) 573-2024

Michele K. Fitzpatrick
Office Phone: 215-898-0154
Appointment Phone: 1-800-789-PENN (7366)