The research performed in the Paterson laboratory is dedicated to harnessing the immune system to provide cures for, or protection against, neoplastic disease. To do this we are using a facultative intracellular bacterium, Listeria monocytogenes, which has the unusual ability to live and grow in the cytoplasm of the cell. Our laboratory was the first to show that this bacterium could be used to target antigens to the MHC class I pathway for antigen processing with the induction of cytotoxic T cells and has pioneered the application of this organism in vaccine development over the past 15 years. Cancers to which we are directing our various technologies currently include cervical cancer, breast cancer, lung cancer, melanoma and lymphoma.

Contact Information

Researcher/Clinician:
Yvonne Paterson

Department of Microbiology
University of Pennsylvania
323 Johnson Pavilion
36th St. and Hamilton Walk
Philadelphia, PA 19104-6076

Office Phone: 215-898-3461
Fax: 215-573-4666

Assistant:
Anita Giacone
Office Phone: 215-573-9870
Appointment Phone: 215-573-9870
Fax: 215-573-4666
anitage@mail.med.upenn.edu

Mailing Address:
Anita Giacone

323 Johnson Pavilion
36th St. and Hamilton Walk
Philadelphia, PA 19104-6076

Office Phone: 215-573-9870
Appointment Phone: 215-573-9870
Fax: 215-573-4666