1974-78 B.Sc. (Hons) Biological Sciences, University of Edinburgh, Edinburgh, Scotland; 1978-82 Ph.D. Imperial Cancer Research Fund Laboratories and University College London, London, UK
Professor of Pathology and Laboratory Medicine
Deputy Scientific Director
Our research addresses the molecular basis of normal and neoplastic growth in the developing nervous system. We hope that by understanding the normal processes that govern formation of the brain we will uncover new approaches for the treatment of rare but very devastating pediatric brain tumors, Research in the laboratory combines basic approaches with genomics and translational science in a broad-based effort. Our experimental strategies include disease models, cell culture, genomics, human tumor samples, imaging and a range of molecular techniques.
Previously, we identified the reelin gene (Reln) whose protein product is a large extracellular protein that controls cell migration and is secreted by several early populations of neurons in the developing brain. We are now examining the molecular events downstream of Reln that mediate its function.
We are taking genomic approaches to identify molecular changes and potential drug targets for several brain tumors including medulloblastoma, atypical teratoid/rhabdoid tumors and choroid plexus carcinomas. We developed a model system with a 100 percent incidence of spontaneous medulloblastoma for use in translational studies. Recently, we found that a small molecule inhibitor of the sonic hedgehog (Shh) pathway eliminated even large tumor masses in vivo. We are continuing to analyze the mechanism of action of several anticancer drugs in tumor cells and cancer models.
Children's Hospital of Philadelphia; Penn Genome Frontiers Institute;
1982-1984 Postdoctoral Fellow, Salk Institute, San Diego, CA
PublicationsClick here to see my publications
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Tom Curran, Ph.D., FRS
The Children's Hospital of Philadelphia Research Institute
Colket Translational Research Building
3501 Civic Center Boulevard
Philadelphia, PA 19104-4318
Office Phone: 267-426-2819
Office Phone: 267-426-2792
Appointment Phone: 267-426-2792