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F. Bradley Johnson, MD, PhD

Abramson Cancer Center

Degree and Institution

PhD, Stanford University School of Medicine; MD, Stanford University School of Medicine

Faculty Title

Assistant Professor, Pathology and Laboratory Medicine

Administrative Title

Assistant Director, Clinical Immunology Laboratory

Clinical Expertise

HLA genotyping and other tests related to transplantation

Research Expertise

We study the Werner and Bloom syndromes, which are caused by loss of the WRN and BLM helicases, respectively, and are characterized by premature aging and elevated rates of cancer. By understanding how WRN and BLM function, we hope to gain insight into mechanisms of aging and carcinogenesis. We are particularly interested in how the WRN and BLM helicases are involved in telomere maintenance. Our experimental systems include mice and yeast cells with mutations in telomerase and in the WRN/BLM family of helicases. We are also interested in how the formation of G-quadruplexes, which can form among telomeric repeats and which are unwound efficiently by the WRN/BLM helicases, may influence cell function.

Residency
Clinical Pathology, Brigham and Woman's Hospital/Harvard Medical School

Fellowship
Institute on Aging, University of Pennsylvania School of Medicine; Pathology, Brigham and Woman's Hospital/Harvard Medical School

Board Certifications
Clinical Pathology

Publications

Click here to see my publications

Contact Information

Researcher/Clinician:
F. Brad Johnson, MD, PhD

405A Stellar Chance Labs
422 Curie Blvd
Philadelphia, PA  19105-6100

Office Phone: 215-573-5037
Fax: 215-573-6317

Assistant:
Insuk Choe
Office Phone: 215-662-6194
Appointment Phone: 215-662-6194
Fax: 215-573-6317
Insuk.Choe@uphs.upenn.edu