Predictive importance of hypoxia and thiols in various human cancers.

Control and measurement of low oxygen levels (hypoxia and anoxia) in vitro; research on cellular and physiological effects of hypoxia;?invasive and non-invasive measurement techniques for hypoxia in tissue; relationship beteen radiation response and oxygen, as modulated by the thiols glutathione and cysteine;?DNA damage and repair after radiation or oxidative stress; oxidative modifications to proteins; quantitative fluorescence microscopy;? immunohistochemistry.