Testicular Cancer Treatment Options at Penn


Different treatments are available for those with testicular cancer. Some treatments are called standard. This means they are the currently used treatments. Some treatments are being tested in clinical trials. A treatment clinical trial is a study meant to help improve current treatments or obtain information on new treatments.

When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. You may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment, while others are available during or after treatment.

Treatment options vary depending on your situation including the stage of the cancer and other factors that may be present.

Talk with your team about the approach that is best for you.

Testicular tumors are divided into 3 groups, based on how well the tumors are expected to respond to treatment.

Good Prognosis

For nonseminoma (a type of cancer of the testicles-seminomas may spread to the lung, bone, liver, or brain) all of the following must be true:

  • The tumor is found only in the testicle or in the retroperitoneum (area outside or behind the abdominal wall); and
  • The tumor has not spread to organs other than the lungs; and
  • The levels of all the tumor markers are slightly above normal.

For seminoma, all of the following must be true:

  • The tumor has not spread to organs other than the lungs; and
  • The level of alpha-fetoprotein (AFP) is normal. Beta-human chorionic gonadotropin (β-hCG) and lactate dehydrogenase (LDH) may be at any level.

Intermediate Prognosis

For nonseminoma, all of the following must be true:

  • The tumor is found in one testicle only or in the retroperitoneum (area outside or behind the abdominal wall); and
  • The tumor has not spread to organs other than the lungs; and
  • The level of any one of the tumor markers is more than slightly above normal.

For seminoma, all of the following must be true:

  • The tumor has spread to organs other than the lungs; and
  • The level of AFP is normal. β-hCG and LDH may be at any level.

Poor Prognosis

For nonseminoma, at least one of the following must be true:

  • The tumor is in the center of the chest between the lungs; or
  • The tumor has spread to organs other than the lungs; or
  • The level of any one of the tumor markers is high.

There is no poor prognosis grouping for seminoma testicular tumors.

Testicular Cancer Treatment Options at Penn

Surgery

Surgery to remove the testicle (radical inguinal orchiectomy) and some of the lymph nodes may be done at diagnosis and staging. Tumors that have spread to other places in the body may be partly or entirely removed by surgery.

Even if the doctor removes all the cancer that can be seen at the time of the surgery, some patients may be given chemotherapy or radiation therapy after surgery to kill any cancer cells that are left. Treatment given after the surgery, to lower the risk that the cancer will come back, is called adjuvant therapy.

Radiation therapy

  • External radiation (or external beam radiation) comes from a machine outside the body. The machine directs high-energy rays at the cancer and some normal surrounding tissue. It is the most often used radiation treatment. The machine used to deliver the high-energy rays is called a linear accelerator.
  • Three-dimensional (3-D) conformal radiation treatment is a type of external beam radiation. It uses computers to allow doctors to more precisely target a tumor with radiation beams (using width, height, and depth). The way the radiation therapy is given depends on the type and stage of the cancer being treated.

Chemotherapy

Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping the cells from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (systemic chemotherapy). When chemotherapy is placed directly into the spinal column, an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas (regional chemotherapy). The way the chemotherapy is given depends on the type and stage of the cancer being treated.

New types of treatment are being tested in clinical trials at Penn.

The Abramson Cancer Center hosts a wide range of materials and activities that provide education and support to address key areas of concern for cancer patients and their loved ones. We are proud that many of our innovative patient education programs have been recognized by national groups, including the National Cancer Institute's Cancer Patient Education Network.

Our educational materials and support activities help people deal with the physical and emotional consequences of a cancer diagnosis and treatment. They also assist patients and families to resume active lives after treatment.

Our support group meetings provide information on topics of ... read more Support

Different treatments are available for those with testicular cancer. Some treatments are called standard. This means they are the currently used treatments. Some treatments are being tested in clinical trials. A treatment clinical trial is a study meant to help improve current treatments or obtain information on new treatments.

When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. You may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment, while others are available during or after treatment.

Treatment options vary depending on your situation including the stage of the cancer and other factors that may be... read more Treatment

The Abramson Cancer Center of the University of Pennsylvania is committed to helping each cancer survivor find ways to enjoy life to the fullest. We have a nationally recognized program that focuses on the issues that survivors face, called "Living Well After Cancer™."

The LIVESTRONG™ Survivorship Center of Excellence, The Living Well After Cancer Program (LWAC) at the Abramson Cancer Center, directed by Linda A. Jacobs, PhD, RN, is a clinical, research, and education effort focused on early intervention and prevention of disease as the ultimate goal.

The multidisciplinary LWAC Program currently provides care and research opportunities to cancer survivors treated at Penn, the University of Pennsylvania Cancer Network hospitals, and through the Living Well ... read more Living Well

Survivor Stories

Rosalinda (Linda) Madara

Rosalinda "Linda" Madara is a loving wife and mother and works as a florist and wedding planner. However, to the staff at the Rena Rowan Breast Center, Linda is the "Cookie Fairy" During her breast cancer treatments, Linda would bring in sweets each morning for the faculty and staff. Her desserts were such a hit that Larry Solin, M.D., her radiation oncologist, suggested that she write a cookbook. Linda started writing that summer, and she completed her 300 recipe cookbook titled, "Sweet Treats and Other Less Sinful Recipes" in 2005. She underwrote all of the publishing costs, and the book is now sold in the Rowan Center Boutique with all proceeds going to support breast cancer research and patient programs.




Spotlight

Stand Up to Cancer

Peter O'Dwyer, MD, professor of Hematology-Oncology and program director of Development Therapeutics in the Abramson Cancer Center, was interviewed on NBC10's 10! Show about Penn's work as part of the Stand Up to Cancer Dream Team... Read more

Testicular Cancer Trials

Phase III Randomized Trial of the Role of Whole Brain Radiation Therapy in Addition to Radiosurgery... more