Gastrointestinal Stromal Tumors (GIST)

About Gastrointestinal Stromal Tumors (GIST)

At Penn Medicine, patients with gastrointestinal stromal tumors (GISTs) receive their care from a multidisciplinary team of nationally recognized experts in the diagnosis, treatment and research of gastrointestinal cancer.  

Gastrointestinal stromal tumors (GISTs) are a type of soft tissue tumor. GISTs are very rare tumors that start in special cells in the wall of the GI tract, called the interstitial cells of cajal. These cells, often called the “pacemaker cells,” regulate body processes like digestion and send signals to the muscles within the gastrointestinal tract to expand and contract, moving food and liquid through the digestive system.

GISTs can occur anywhere within the digestive tract, but are found most frequently in the stomach or small intestine.

Penn Medicine’s multidisciplinary approach to cancer diagnosis and treatment provides better outcomes and gives patients with GIST access to the most advanced treatment, surgical techniques and clinical trials.

Because navigating a cancer diagnosis and treatment options can be difficult, patients who wish to connect with a cancer specialist at Penn Medicine can speak with a cancer nurse, who can help them make an appointment with the right physician.

To connect with a cancer nurse at Penn Medicine, patients should call 800-789-PENN.

Read more About Gastrointestinal Stromal Tumors (GIST)

Diagnosing Gastrointestinal Stromal Tumors (GIST)

An accurate cancer diagnosis from trusted cancer specialists is the first step in getting personalized treatment options to treat gastrointestinal stromal tumors (GISTs).

Patients who choose Penn Medicine’s Abramson Cancer Center, benefit from a multidisciplinary team of cancer specialists including gastroenterologists, radiologists, pathologists and surgeons who work together to provide a diagnosis and treatment plan custom designed for each patient with GISTs.

Cancer specialists at Penn Medicine are highly experienced in using the most advanced techniques for diagnosing gastrointestinal stromal tumors and are actively researching better and more precise ways to detect GISTs.

Navigating a cancer diagnosis and treatment options can be difficult, patients who wish to connect with a cancer specialist at Penn Medicine can speak with a cancer nurse, who can help them make an appointment with the right person. Penn Medicine’s contact center has experienced cancer nurses available and ready to guide patients in finding the cancer specialist right for them.

To connect with a cancer nurse at Penn Medicine, patients should call 800-789-PENN (7366).

Read more Diagnosing Gastrointestinal Stromal Tumors (GIST)

Gastrointestinal Stromal Tumor (GIST) Treatment

Following the diagnosis and staging of GISTs, cancer specialists at Penn’s Abramson Cancer Center develop a personalized treatment plan. Penn’s treatment options for GISTs include:

  • Surgery
    • Local excision
    • Low anterior resection
    • Liver resection
    • Radiofrequency ablation
  • Radiation therapy
  • Chemotherapy and biologic therapies
    • Targeted therapies
  • Clinical trials
  • Other treatments
    • Integrative medicine and wellness
    • Palliative care
    • Penn Home Care and Hospice

Because navigating a cancer diagnosis and treatment options can be difficult, patients who wish to connect with a cancer specialist at Penn Medicine can speak with a cancer nurse, who can help them make an appointment with the right physician.

To connect with a cancer nurse at Penn Medicine, patients should call 800-789-PENN (7366).

Read more Gastrointestinal Stromal Tumor (GIST) Treatment

Gastrointestinal Stromal Tumor (GIST) Survivorship

There are more than 12 million cancer survivors living and thriving today as a result of advances in cancer treatment. However, cancer treatments can result in physical, emotional and financial complications long after the therapy is complete. Survivorship programs at Penn Medicine are a distinct phase of gastrointestinal stromal tumor (GIST) care and are designed to help patients' transition from their cancer treatment routine to a post-cancer care lifestyle.

Read more Gastrointestinal Stromal Tumor (GIST) Survivorship


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