Anal Cancer

About Anal Cancer

At Penn Medicine's Abramson Cancer Center, patients with anal cancer receive their care from a multidisciplinary team of nationally recognized experts in the diagnosis, treatment and research of gastrointestinal cancer.

The anus is at the end of the digestive tract below the rectum. The anal canal is a three- to four-centimeter long structure between the anal sphincter, a muscle that controls bowel continence, and the anal margin, the area of skin just outside of the digestive tract. The anus is the opening of the rectum to the outside of the body.

There are two types of anal cancer:

  • Anal margin: Visible on the skin outside of the anus
  • Anal canal: Cannot be seen on the outside of the anus

Anal cancer is not very common and accounts for only 1 to 2 percent of all gastrointestinal cancers.

Penn Medicine's multidisciplinary approach to cancer diagnosis and treatment provides better outcomes and gives patients access to the most advanced treatment, surgical techniques and clinical trials. This multidisciplinary approach has a dual goal of anal conservation and cure of disease.

Because navigating a cancer diagnosis and treatment options can be difficult, patients who wish to connect with a cancer specialist at Penn Medicine can speak with a cancer nurse, who can help them make an appointment with the right physician.

To connect with a cancer nurse at Penn Medicine, patients should call 800-789-PENN (7366).

Read more About Anal Cancer

Diagnosing Anal Cancer

An accurate cancer diagnosis from trusted cancer specialists is the first step in getting personalized treatment options to treat anal cancer.

Patients who choose Penn's Abramson Cancer Center, benefit from a multidisciplinary team of cancer specialists including medical oncologists, gastroenterologists, radiologists, pathologists and surgeons who work together to provide a diagnosis and treatment plan designed specifically for each patient with anal cancer.

Cancer specialists at Penn Medicine are highly experienced in using the most advanced techniques for diagnosing anal cancer.

Navigating a cancer diagnosis and treatment options can be difficult. Patients who wish to connect with a cancer specialist at Penn Medicine can speak with a cancer nurse who can help them make an appointment with the right person. Penn Medicine’s contact center has experienced cancer nurses available and ready to guide patients in finding the cancer specialist right for them.

To connect with a cancer nurse at Penn Medicine, patients should call 800-789-PENN (7366).

Read more Diagnosing Anal Cancer

Anal Cancer Treatment

Following the diagnosis and staging of anal cancer, cancer specialists at Penn Medicine’s Abramson Cancer Center develop a personalized treatment plan.

Anal margin cancer, otherwise known as “perianal cancer” is treated with surgery to remove the growth.

Anal canal cancer is usually treated with a combination of chemotherapy and radiation.  Surgery is rarely needed in cases of anal canal cancer. 

In all cases of anal cancer, Penn cancer specialists are committed to doing everything they can to conserve the anus and anal tissue.

Penn’s treatment options for anal margin cancer include:

  • Surgery
    • Local resection

Penn’s treatment options for anal canal cancer include:

  • Radiation therapy
    • 3-D conformal radiation
    • Intensity-modulated radiation therapy (IMRT)
    • Volumetric-modulated arc therapy (VMAT)
    • Proton therapy
  • Chemotherapy and biologic therapies
  • Surgery
    • Local resection

Other possible treatment options for anal margin and canal cancer include:

  • Clinical trials
  • Other treatments
    • Integrative medicine and wellness
    • Palliative care
    • Penn Home Care and Hospice

Because navigating a cancer diagnosis and treatment options can be difficult, patients who wish to connect with a cancer specialist at Penn Medicine can speak with a cancer nurse, who can help them make an appointment with the right physician.

To connect with a cancer nurse at Penn Medicine, patients should call 800-789-PENN (7366).

Read more Anal Cancer Treatment

Anal Cancer Survivorship

Survivorship programs at Penn Medicine are a distinct phase of anal cancer care and are designed to help patients transition from their cancer treatment routine to a post-cancer care lifestyle. There are more than 12 million cancer survivors living and thriving today as a result of advances in cancer treatment. However, cancer treatments can result in physical, emotional and financial complications long after the therapy is complete.

Read more Anal Cancer Survivorship


Perry Rothaus

A fifteen-year cancer survivor, Perry Rothaus feels that not enough attention is given to caregivers, and he credits his wife, Judi, with his survival. Judi researched his type of cancer, decided on the Abramson Cancer Center for his care, and and a

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