Susan Domchek, MD was funded to comprehensively investigate the effect of risk-reducing oophorectomy on a variety of health outcomes. Findings from this study will be helpful in advising patients on the best timing for oophorectomy and in establishing whether interventions to treat side effects are needed.
Timothy Rebbeck, PhD has been awarded funding to study factors that modify BRCA1/2 cancer risks in carriers to provide information that may aid women and their providers in making optimal decisions about cancer prevention strategies.
Andrea Facciabene, PhD has been working to study and develop a potential vaccine for BRCA-related cancers that may teach the immune system to react to and destroy cancerous tissue.
Roger Greenberg, MD, PhD has been funded to study other DNA errors present in BRCA-related cancers to determine if these errors predict response to certain therapies, towards the end of developing better chemotherapy approaches based on the specific genetic changes in BRCA-related cancers.
Andrew Minn, MD, PhD had been funded to study changes in the DNA of BRCA-related tumors to evaluate whether these DNA changes predict response to chemo- and radiation therapies in order to determine optimal treatment strategies.
Kate Nathanson, MD, has been funded to sequence the DNA of breast and ovarian tumors for BRCA1/2 carriers to understand the molecular changes that may represent new targets for treatment or predict drug sensitivity or resistance to current regimens.
Drs. George Coukos and Chungsheng Li investigate innovative molecular imaging techniques that visualize the tiny veins that grow to feed cancers which could lead to better methods for early detection of BRCA-related cancers.
Dr. Rhim's laboratory recently found that cells from the pancreas (and other organs) can enter the bloodstream when a pre-cancerous lesion is present but long before a tumor has formed. Dr. Rhim's work focuses on applying this discovery to develop a screening method for detecting BRCA-related cancers early.
Dr. Angela Bradbury was awarded Basser funding to study communication about hereditary cancer risk within families, with a focus on adolescents. Her work aims to inform interventions that increase preventative behaviors and minimize adverse psychological outcomes in adolescents and young adults from BRCA families.