Basser Investigator Publications
Investigators at the Basser Research Center for BRCA publish in a wide range of peer-reviewed journals focused on all aspects of cancer and genetics such as Journal of Clinical Oncology, Cancer, Breast Cancer Research and Treatment, PLOS Genetics, Nature Genetics, Nature Structural and Molecular Biology, Cancer Discovery, Journal of Medical Genetics, and many more.
Basser-Funded Team Finds Ovarian Cancer Oncogene in "Junk DNA"
Basser-funded investigator Lin Zhang, MD, Research Associate Professor in the Department of Obstetrics and Gynecology at the Perelman School of Medicine at the University of Pennsylvania, mined “junk DNA,” or what lies outside of protein-coding genes, and recently identified a non-protein coding RNA whose expression is linked to ovarian cancer. This discovery provides a potential biomarker of BRCA-related cancer and the potential for new anti-cancer therapeutics. The study was published in Cancer Cell. Read more about this discovery and publication here.
Penn Researchers Explain How Ends of Chromosomes are Maintained for Cancer Cell Immortality
Maintaining the ends of chromosomes, called telomeres, is a requisite feature of cells that are able to continuously divide and also a hallmark of human cancer. “Telomeres are much like the plastic cap on the ends of shoelaces -- they keep the ends of DNA from fraying,” says Roger Greenberg, MD, PhD, Associate Professor of Cancer Biology in the Perelman School of Medicine at the University of Pennsylvania and Director of Basic Science for the Basser Research Center for BRCA. In a new study published in Cell
, he and his colleagues describe a mechanism for how cancer cells take over one of the processes for telomere maintenance to gain an infinite lifespan. Read more about this discovery and publication here
Basser-Funded Team Describes Cell Communications That Contribute to Treatment Resistance in Breast Cancer Patients
In a new study published in the journal Cell, Andy J. Minn, MD, assistant professor of Radiation Oncology at the Perelman School of Medicine and the Abramson Family Cancer Research Institute, and colleagues report findings from a preclinical study investigating the communication between stromal cells (those in the microenvironment of the tumor) and cancer cells in an effort to better understand treatment resistance in breast cancer patients. The researchers revealed a “crosstalk” between both sets of cells using paracrine and juxtacrine signaling—which increased the number of therapy-resistance cancer cells. Identifying such pathways not only provides insight into important biological mechanisms but also potential biomarkers for prognosis, prediction, and therapy. Read more here
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